Brandefy Clinical Vit C + E + Ferulic Defend Serum in an amber glass dropper bottle with a light blue label reading 15% L-ascorbic acid.
Vitamin C / off patent since 2025
4.71 out of 5 · 919 reviews

That famous $185 serum? The patent expired.

For twenty years one company had the legal right to sell that formula, and priced it accordingly. That right ran out on March 24, 2025. Our L-ascorbic acid based vitamin C serum is $55.

Brandefy's Clinical Vit C + E + Ferulic Defend Serum

  • 15% L-ascorbic acid, vitamin E and ferulic acid
  • Same chemists/manufacturers that make other high-end clinical skincare
  • No retail markup, sold direct
  • 30-day money-back guarantee
30 ml · Custom formulated in the United States

Testimonials from customers who switched

Rated 5 out of 5

Great Stuff

“I am a 30 year old mom of 2 and usually use the best vitamin C on the market and they are very expensive. I love this stuff and will purchase again. It is very similar and my skin looks great.”

Brittany · Verified buyer · April 2026
Rated 5 out of 5

Great quality

“This is the first time I tried this product and so far I have found it to be a great product. It is very comparable to the expensive product I have used for years. I will definitely continue to use this product and recommend to my friends.”

Leigh P. · Verified buyer · February 2026
Rated 5 out of 5

Love this product!

“Thank you for making this product! had purchased the SkinCeuticals product a couple of times but I couldn’t justify the cost. This product feels similar to the original and works well on my skin. Just purchased my 2nd bottle.”

Kristen M. · Verified buyer · June 2026

Received a coupon toward a future order in exchange for this review.

85%

of surveyed customers said their skin looked more radiant after using the Defend Serum — 41 of 48.

Brandefy customer survey, October 2023. n = 48; 41 of 48 respondents answered yes, and all 48 answered the question. Panel members received an incentive to respond. Self-reported appearance, not a clinical measurement.

Customer before and after using Brandefy Clinical Vit C + E + Ferulic Defend Serum

Brandefy Clinical Vit C + E + Ferulic Defend Serum, before and after. Individual result; see note below.†


What’s in our Vitamin C bottle

Three actives, each doing a specific job. 15% L-ascorbic acid — pure vitamin C, the form skin can actually use — to help support a brighter, more even-looking tone. Vitamin E alongside it. And 0.5% ferulic acid, which holds the other two stable long enough to do their work.

The $185 original has the same three, both at 15% L-ascorbic acid. Beyond that they are two different formulations, made by two different sets of chemists.


Think of us as high-end dupes.

Brandefy works with the chemists, manufacturers and dermatologists who make other high-end clinical skincare.

Everything wrapped around a $185 bottle — the counter, the retailer’s margin, the campaign — is priced into it.

Meg Pryde, Brandefy's founder, speaking to camera in a home office with a floral upholstered panel behind her.
Meg Pryde, founder

How is it only $55?

A serum on a department store shelf has to pay for the shelf. It pays the retailer, the counter staff, the sampling program and the campaign that got you to walk over. By the time it reaches you, everyone who touched it has been paid out of the price.

Ours goes from the lab to a box to you. That is not a smaller margin on the same product — it is a shorter list of people getting paid.


What actually expired

US Patent 7,179,841 B2 was filed on January 11, 2005 and issued on February 20, 2007. It described a single-phase solution: L-ascorbic acid, a cinnamic acid derivative — ferulic acid is one — a solvent system and water, held at a pH of no more than about 3.5, with vitamin E optional. That is the architecture that keeps pure vitamin C stable long enough to be worth putting on your face.

The named inventors are Jan E. Zielinski and Sheldon R. Pinnell, a Duke dermatologist who spent much of his career on this exact problem and solved it. The patent itself was assigned to L’Oréal USA Creative, Inc., and sits today with L’Oréal USA S.D. Inc.

A patent is a trade: twenty years of exclusivity, and then the knowledge belongs to everybody. The twenty years are up. It expired on March 24, 2025, and since that date any company may legally make what it describes.

Brandefy Clinical Vit C + E + Ferulic Defend Serum in an amber glass dropper bottle with a light blue label.
Brandefy

Clinical Vit C + E + Ferulic Defend Serum

4.71 out of 5 · 919 reviews
$55 Theirs is $185.
  • 30 ml / 1 fl oz
  • 15% L-ascorbic acid · vitamin E · 0.5% ferulic acid
  • Custom formulated in the United States
  • Ships in the US, PO boxes included
Use it in the morning, before sunscreen.

The vitamin C isn’t the only one

Three more we make the same way.

Brandefy Tri Lipid Replenish Treatment in a clear glass jar with a white lid and light blue label.
Moisturizer

Tri Lipid Replenish Treatment

$65 Theirs is $155.
Inspired by SkinCeuticals Triple Lipid Restore.

A highly effective concentration of 1.5% ceramides, 4.0% pomegranate sterols & 1.8% fatty acids.

Brandefy No Needles Renew Serum in an amber glass bottle with a black dropper cap and a pink label.
Serum

No Needles Renew Serum

$35 Theirs is $69.
Inspired by DRMTLGY Needle-less Serum.

Built on the same three actives: 4% niacinamide, five molecular weights of hyaluronic acid, and a peptide complex.

Brandefy WaterCream Refresh Moisturizer in a white jar with a mint green label.
Moisturizer

WaterCream Refresh Moisturizer

$35 Theirs is $74.
Inspired by Tatcha Water Cream.

Niacinamide (Vitamin B3) helps soften the look of visible pores and fine lines.


Questions

What’s the same, and what isn’t?

Same three actives, both at 15% L-ascorbic acid — vitamin E and ferulic acid are the other two. Beyond that they are two different formulations by two different sets of chemists.

Is this legal?

Yes, and it is the ordinary end of the process. A patent grants twenty years of exclusivity in exchange for publishing how the thing works. When the twenty years end, the description is public property. That happened on March 24, 2025.

Why is it so much less?

Because nothing between the lab and your door is taking a cut, and because the formula is no longer exclusive to anyone. Neither of those is a saving on the chemistry.

How long before I see anything?

Topical vitamin C generally takes around eight weeks to make a visible difference to tone and elasticity. Use it in the morning, before sunscreen, every day.

†Before and after photographs are submitted by individual customers. Results are that individual’s experience and are not typical. Outcomes vary with skin type, routine, consistency of use and sun exposure; no particular result is promised or implied.

US Patent 7,179,841 B2, “Stabilized ascorbic acid compositions and methods therefor” — filed January 11, 2005; issued February 20, 2007; originally assigned to L’Oréal USA Creative, Inc. and currently held by L’Oréal USA S.D. Inc.; expired March 24, 2025. Searchable at patents.google.com.

Competitor prices verified 4 August 2026: SkinCeuticals C E Ferulic $185 and Triple Lipid Restore 2:4:2 $155 at authorized retailers; DRMTLGY Needle-less Serum $69 and Tatcha The Water Cream $74 at those brands’ own stores. Prices are set by those brands and are subject to change.

SkinCeuticals, C E Ferulic, Triple Lipid Restore, DRMTLGY, Needle-less, Tatcha and The Water Cream are trademarks of their respective owners, which are not affiliated with Brandefy and do not endorse it. Comparisons refer to active ingredients and price only. Individual results vary.

Clinical Vit C + E + Ferulic Defend Serum
$55